基于Hippo信号通路探讨中医药治疗肝纤维化的研究进展OA

Hepatic fibrosis is a critical pathological stage in the progression of many chronic liver diseases toward cirrhosis and even hepatocellular carcinoma.The Hippo signaling pathway is an evolutionarily highly conserved signal transduction pathway.Dysregulation of the Hippo signaling pathway is associated with key processes in hepatic fibrosis,including HSC activation,ECM deposition,and cell apoptosis and senescence.Many ac-tive ingredients and formulas of traditional Chinese medicine(TCM)have been shown to delay or even reverse the progres-sion of hepatic fibrosis by regulating the expression of key mol-ecules in the Hippo signaling pathway,inhibiting HSC activa-tion,modulating HSC apoptosis and senescence,reducing ECM deposition,influencing macrophage polarization,and crosstalking with critical pathways such as TGF-β/Smad,Hedge hog,and AMPK.This article aims to summarize the mecha-nisms of the Hippo signaling pathway in hepatic fibrosis and sys-tematically review the latest research on TCM interventions tar-geting this pathway,thereby providing new reference for the TCM treatment of hepatic fibrosis.