基于UPLC指纹图谱、多元统计分析、含量测定比较3种天麻钩藤饮制剂质量OA

AIM To compare the quality of traditional decoction,intelligent decoction and personalized granules of Tianma Gouteng Drink.METHODS The UPLC fingerprint were established,after which principal component analysis,orthogonal partial least squares-discriminant analysis and hierarchical cluster analysis were performed,the contents of gastrodia,geniposide,pinoresinol diglucoside,2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside,baicalin and wogonoside were determined.RESULTS There were 30 common peaks in the fingerprints for 9 batches of samples with the similarities of 0.976-0.997.Three preparations could be obvisously distinguished,among which the traditional decoction and intelligent decoction were more similar,whose material expression quantities were higher than that of the personalized granules.The highest contents of index components in the intelligent decoction were observable,followed by those in the traditional decoction,and those in the personalized granules were the lowest,whose transfer rates from the intelligent decoction to the personalized granules were 86.27％-102.23％.CONCLUSION The preparation method of intelligent decoction and personalized granules of Tianma Gouteng Drink are stable and feasible,which can provide a reference for the further research on related intelligent equipments.