基于夙根理论探讨儿童过敏性鼻炎-哮喘综合征的形成与干预OA

Combined allergic rhinitis and asthma syndrome(CARAS)is a common childhood chronic respiratory disease,characterized by recurrent episodes and a protracted,difficult-to-cure course.Traditional Chinese medicine(TCM)attributes its recurrent and prolonged nature to the formation of a"root pathogen"pathology,which encompasses latent wind,retained phlegm,phlegm-stasis intermingling,and constitutional deficiency.These correspond respectively to the modern pathological mechanisms of specific IgE-mediated hypersensitivity,persistent chronic airway inflammation,tissue ischemia and hypoxia,and immune dysregulation resulting from cellular interactions.Drawing upon the TCM root pathogen theory and integrating modern understanding of pathogenesis,this study proposes an intervention strategy for CARAS that includes"dispelling wind and eliminating the root pathogen to suppress hypersensitivity;resolving phlegm and regulating the lung to relieve asthma;removing stasis and transforming phlegm to unblock the collaterals;and reinforcing healthy Qi and supplementing deficiency to consolidate the root".This approach aims to eliminate the root pathogen,restore normal Qi movement,and improve allergic constitution,inflammatory status,hypoxic state,and immune imbalance in patients,thereby offering new perspectives for the TCM-based prevention and treatment of pediatric CARAS.