从"伏邪伤阳"探索艾滋病免疫重建不全的治疗策略OA

Immunological non-response(INR)remains a bottleneck in the current treatment of AIDS.Based on the traditional Chinese medicine(TCM)theory of"Latent Pathogens"and the specific characteristics of human immunodeficiency virus(HIV)infection,we posit that the pathological nature of INR is rooted in Yang deficiency,characterized by a complex mixture of deficiency and excess."Latent pathogens damaging Yang"constitutes the core pathogenesis.Addressing the specific pathogenic mechanisms whereby pathogens lurk in the lesser Yin(damaging kidney Yang)and strike the greater Yin(consuming spleen Yang),we propose a therapeutic philosophy that"prioritizes harmony and facilitates physiological order".This is guided by the treatment principle of"simultaneously expelling latent pathogens and supporting Yang".Drawing upon the theory of"latent pathogens damaging Yang"and synthesizing previous research findings,this paper reviews and summarizes the therapeutic principles and methods for INR.Furthermore,it explores treatment strategies at both the individual and population levels,aiming to provide novel insights and clinical pathways for the TCM management of INR.