经典名方调节高血压的内分泌机制及活性成分研究进展OA

This article focuses on the three major endocrine/neuroregulatory systems associated with hypertension—the renin-angiotensin-aldosterone system(RAAS),the hypothalamic-pituitary-adrenal axis(HPA axis),and the sympathetic nervous sys-tem(SNS)—to review modern research and ongo-ing controversies surrounding classical compound prescriptions(empirical formulas/classic prescrip-tions)and their active ingredients in the interven-tion of hypertension.The review emphasizes the pharmacological evidence pertaining to compo-nents such as flavonoids,alkaloids,and saponins,while also discussing the boundaries of the"TCM syndrome–endocrine marker"correspondence,the safety prerequisites for toxic components(e.g.,aconitine),and the bottlenecks in clinical transla-tion.Current evidence primarily consists of cell and animal studies,with high-quality randomized con-trolled trials remaining insufficient;therefore,fu-ture research should adopt more standardized study designs to enhance the level of evidence.