缩醛磷脂在阿尔茨海默病中的研究进展OA

Alzheimer's disease(AD)is a progres-sive neurodegenerative disorder with complex pathogenesis and limited current treatment op-tions,urgently requiring new intervention targets.Plasmalogen,a naturally occurring glycerophospho-lipid,is widely distributed in cell membranes(such as myelin sheaths)and certain foods(such as seafood).Not only do they exhibit significant anti-inflammatory and antioxidant activities,but they have also been demonstrated to participate in memory enhancement.Growing evidence indicates that reduced plasmalogens levels are closely associ-ated with the onset and progression of AD.Plas-malogens can target multiple key mechanisms to in-tervene in AD pathological processes,including clearing amyloid-β(Aβ)deposits,inhibiting apopto-sis,promoting neurogenesis,and reducing exces-sive activation of microglia,thereby exerting neuro-protective effects.Therefore,supplementing with plasmalogens holds promise as a novel strategy for preventing and treating AD.This article aims to summarize and explore the latest research ad-vances on plasmalogens in AD pathogenesis and therapeutic interventions,with the goal of provid-ing new directions for further AD research and treatment.