民族药用植物非洲马铃果最新研究进展OA

Voacanga africana Stapf a member of the Apocynaceae family,is an introduced medicinal plant with both long-standing traditional therapeutic use and considerable potential for modern development.Rich in bioactive constituents such as monoterpene indole alkaloids,it represents a valuable resource for natural product research and medicinal exploitation.Building on previous studies,this review systematically summarizes research advances since 2020 on the chemical constituents and biological activities of V.africana,the pharmacological effects of its extracts,and the extraction and isolation of its major active constituent,(-)-tabersonine,as well as its application in the synthesis of bioactive molecules.Recent studies have reported 34 new compounds from V.africana,representing nine structural types,most of which are monoterpene indole alkaloids,with activities including antitumor,antiplasmodial,antibacterial,and antiviral effects.In addition,because(-)-tabersonine is relatively abundant in the seeds and can be obtained with comparative ease,it has become a major focus for the high-value utilization of this plant and has increasingly been explored in semisynthesis,biotransformation,and synthetic biology.Overall,research on V.africana has evolved from traditional evaluations of crude extract activity toward an integrated emphasis on the discovery of active constituents and their functional utilization.Nevertheless,further work is still needed to clarify the chemical differences among distinct plant parts,the relationship between extract activity and individual active constituents,and strategies for the high-value utilization of this resource.This review provides a useful reference for studies on the pharmacodynamic material basis of V.africana and for its further resource development and utilization.