老年肺癌患者免疫相关不良反应的临床特征及危险因素分析OA

Objective To analyze the clinical characteristics and independent risk factors of grade≥2 immune-related adverse events(irAEs)in elderly patients with lung cancer receiving immune checkpoint inhibitors(ICIs).Methods A total of 162 patients aged≥65 years with lung cancer who received ICIs for the first time at our hospital between December 2021 and December 2024 were retrospectively included.According to the Common Terminology Criteria for Adverse Events(CTCAE)version 5.0,patients were divided into an irAE group(n=46)and a non-irAE group(n=116).Logistic regression analysis was performed to identify independent risk factors for irAEs.Results The overall incidence of grade≥2 irAEs was 28.4%(46/162),with thyroid dysfunction(34.8%)and rash(23.9%)being the most common types.Multivariable analysis showed that combination therapy and baseline autoantibody positivity were independent risk factors for grade≥2 irAEs in elderly patients with lung cancer.Conclusion In elderly patients with lung cancer,irAEs were most commonly manifested as thyroid dysfunction and rash.Patients receiving combination therapy and those with baseline autoantibody positivity may be at higher risk and should therefore receive closer monitoring and individualized management throughout treatment.