纳米酶调控线粒体代谢治疗炎症性疾病的研究进展OA

The core pathology of inflammatory diseases lies in the interaction between abnormal activation of immune cells and metabolic homeostasis imbalance,which jointly lead to the persistence of chronic inflammation.In immune cells,the burst of reactive oxygen species centered on mitochondria and the reprogramming of metabolism play a crucial role.Therefore,regulating immune metabolism to maintain immune homeostasis is of great significance.With the development of nanozyme delivery systems,therapeutic strategies utilizing nanozymes to target subcellular structures have become a promising frontier in biomedical research.By targeting the subcellular structure of mitochondria to deliver nanozymes and bioactive molecules,it is expected to reprogram the energy metabolism centered on mitochondria,further reshape the phenotype of immune cells,and correct the pathological microenvironment of immune metabolic imbalance.This review systematically summarizes the association mechanisms between mitochondrial metabolism and inflammatory diseases,the latest research progress of nanozymes in the treatment of such diseases,and the key challenges in clinical translation.By exploring the action mechanisms and therapeutic potential of nanoformulations targeting mitochondria in the inflammatory microenvironment,it aims to provide references for the design of intelligent nanomaterials for the treatment of inflammatory diseases.