121例输血患者不良反应发生情况及相关因素分析OA
Occurrence and Associated Factors of Adverse Transfusion Reactions in 121 Patients
目的 对 121 例输血患者不良反应进行调查,并分析其相关因素,为提高输血安全性提供依据.方法 回顾性选取濮阳市中医医院2021年6月至2023年12月接受输血治疗的121例患者临床资料,统计非溶血性发热反应、过敏、溶血性反应等不良反应发生情况及类型,依据是否发生输血不良反应分为发生组和未发生组,分析输血不良反应的相关因素,比较两组患者一般资料、输血类型、输血次数、血液储存时间、滴注速度、原发性血液病史、发血-输血间隔时间等,分析输血不良反应发生的相关因素.结果 121 例接受输血的患者中,24 例记录有输血不良反应,仅患者层面不良反应占比19.83%,共统计不良反应事件24起,其中非溶血性发热6例,占比4.96%;过敏反应11例,占比9.09%;溶血性反应 5 例,占比 4.13%;其他不良反应 2 例,占比 1.65%;发生组年龄、输血次数、发血-输血间隔时间均高于未发生组(P＜0.05);多因素回归分析显示,年龄、输血次数、发血-输血间隔时间均是输血不良反应发生的相关因素(P＜0.05).结论 患者层面输血不良反应占比 19.83%,加强输血不良反应的监测,针对年龄、输血次数、发血-输血间隔时间等相关因素采取相应的预防措施,降低输血不良反应的发生率,提高输血安全性.
Objective To investigate adverse transfusion reactions in 121 patients and analyze their associated factors,thereby providing evidence for improving transfusion safety.Methods The clinical data of 121 patients who received blood transfusion at Puyang Hospital of Traditional Chinese Medicine from June 2021 to December 2023 were retrospectively analyzed.The occurrence and types of adverse transfusion reactions,including non-hemolytic febrile reactions,allergic reactions,and hemolytic reactions,were recorded.According to whether an adverse transfusion reaction occurred,the patients were divided into a reaction group and a non-reaction group.General characteristics,type and frequency of transfusion,blood storage duration,infusion rate,history of primary hematologic disease,and the interval between blood issue and transfusion were compared between the two groups.Factors associated with adverse transfusion reactions were further analyzed.Results Among the 121 patients who received transfusion,24 experienced adverse transfusion reactions,corresponding to a patient-level incidence of 19.83%.A total of 24 adverse reaction events were recorded,including 6 non-hemolytic febrile reactions(4.96%),11 allergic reactions(9.09%),5 hemolytic reactions(4.13%),and 2 other adverse reactions(1.65%).Age,number of transfusions,and the interval between blood issue and transfusion were higher or longer in the reaction group than in the non-reaction group(P＜0.05).Multivariable regression analysis showed that age,number of transfusions,and the interval between blood issue and transfusion were associated with the occurrence of adverse transfusion reactions(P＜0.05).Conclusion The patient-level incidence of adverse transfusion reactions was 19.83%.Strengthening surveillance for adverse transfusion reactions and implementing targeted preventive measures according to associated factors such as age,number of transfusions,and the interval between blood issue and transfusion may help reduce adverse reactions and improve transfusion safety.
孟瑞花;徐少帅;赵振军
濮阳市中医医院 输血科,河南 濮阳 457000濮阳市中医医院 输血科,河南 濮阳 457000濮阳市中医医院 输血科,河南 濮阳 457000
输血不良反应调查相关因素安全性
adverse transfusion reactioninvestigationassociated factorssafety
《临床研究》 2026 (10)
41-44,4
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