从靶向取精到生精功能重建:治疗性睾丸精子获取技术的演进与临床应用OA
From targeted sperm retrieval to spermatogenic function reconstruction:evolution and clinical applica-tion of therapeutic testicular sperm retrieval techniques
治疗性睾丸精子获取与临床应用是无精子症及严重男性不育患者实现生物学生育的重要手段.近年来在获取技术优化、临床适应人群拓展及再生医学探索方面均取得了重要进展.本文以"靶向取精到生精功能重建"为核心主线,系统回顾了治疗性睾丸精子获取技术的两段技术突破,总结其在辅助生殖与生育力保存中的研究进展,分析当前面临的主要挑战,并展望未来发展方向,旨在为临床规范化诊疗及基础研究成果转化提供参考.
Therapeutic testicular sperm retrieval and clinical application are essential for achieving biological parenthood in patients with azoospermia and severe male infertility.In recent years,significant progress has been made in the optimization of retrieval techniques,expansion of clinical indications,and exploration of regenerative medicine strategies.Focusing on the core theme of"from targeted sperm retrieval to spermatogenic function recon‑struction",this article systematically reviews the evolution of therapeutic testicular sperm retrieval techniques from blind biopsy and targeted localization to functional spermatogenesis reconstruction,and summarizes the research progress in assisted reproduction and fertility preservation,analyzes the current challenges,and discusses future directions.This review aims to provide reference for clinical standardized diagnosis and treatment as well as transla‑tional research of basic science.
罗璐璐;唐雨倩;马春杰
广东省生殖科学研究所(广东省生殖医院)国家卫生健康委员会男性生殖与遗传重点实验室(广东 广州 510600)广东省生殖科学研究所(广东省生殖医院)国家卫生健康委员会男性生殖与遗传重点实验室(广东 广州 510600)广东省生殖科学研究所(广东省生殖医院)国家卫生健康委员会男性生殖与遗传重点实验室(广东 广州 510600)
医药卫生
无精子症治疗性睾丸精子获取再生医学辅助生殖生育力保存
azoospermiatherapeutic testicular sperm retrievalregenerative medicineassisted re‑productionfertility preservation
《实用医学杂志》 2026 (17)
3197-3205,9
广东省医学科学技术研究基金项目(编号:B2024121)
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