"肝主谋虑、胆主决断"认知神经机制的重构OA

Inhibitory control impairment is a core cognitive deficit in early mild cognitive impairment(MCI).However,a systematic cognitive-neural interpretation of liver governing deliberation and gallbladder governing decision-making remains lacking.Based on the dual-component theory of inhibitory control,this study proposes a correspondence framework:interference control maps to liver governing deliberation,operating via the DLPFC-ACC circuit under dopaminergic regulation;response inhibition maps to gallbladder governing decision-making,centering on the rIFG-basal ganglia-thalamic circuit with serotonergic and noradrenergic co-regulation.Drawing upon this prefrontal-thalamic-basal ganglia circuitry,we preliminarily elucidate a closed-loop mechanism for synergistic liver-gallbladder cognitive regulation,and suggest that N2,P2,and P300 components may serve as electrophysiological markers for liver-gallbladder imbalance-mediated cognitive impairment.These findings provide a scientific basis for modernizing the liver visceral manifestation theory,enabling early microscopic syndrome differentiation of MCI,and guiding liver-soothing interventions.They also further enrich the liver depression leading to brain degeneration.