注射用艾沙康唑临床应用分析及合理性评价OA

Objective To explore the current clinical application status of Isavuconazole for injection,analyze the types and distribution characteristics of irrational drug use,and provide a basis for standardizing the use of antifungal drugs,improving treatment outcomes,reducing adverse reactions,and curbing drug resistance.Methods The medical records of 376 patients who used Isavuconazole for injection in the First People's Hospital of Qinzhou from January 2024 to December 2025 were retrospectively analyzed.Through dimensions such as department distribution,types of irrational drug use,and adverse drug reactions(ADR),a systematic evaluation of the rationality of drug use and influencing factors was conducted.Results The number of cases in the intensive care unit was the highest(132 cases,35.11％),followed by the respiratory internal medicine department(102 cases,27.13％).There were a total of 39 cases(10.37％)of irrational drug use,with the main type being drug interactions(15 cases,accounting for 3.99％of the total cases).Secondly,there were 9 cases of off-label drug use(2.39％),and 7 cases of inappropriate dosage(1.86％).The incidence of ADR was 7.18％(27 cases),mainly neurological symptoms(10 cases,2.66％)and abnormal liver function(7 cases,1.86％).Conclusion Isavuconazole for injection is in-creasingly widely used in clinical antifungal treatment in the First People's Hospital of Qinzhou,but there are still cases of irrational drug use in clinical application.It is necessary to strengthen the control of indications,monitor drug interactions,and optimize individualized drug administration regimens.