突发性聋发病机制及患者发病影响因素logistic回归分析OA

Objective To explore the pathogenesis of sudden deafness,and to analyze the related influencing factors by lo-gistic regression model.Methods The clinical data of 200 patients with sudden deafness admitted to the Department of O-torhinolaryngology,Pingtan Comprehensive Experimental Area Hospital from September 2023 to September 2025 were retrospectively analyzed,and they were set as the study group.The basic diseases,personal history,basic information,and laboratory examination results of the patients were collected.In addition,200 healthy hearing people who came to the hospital for physical examination during the same period were selected as the control group.The clinical data of the two groups were compared.Univariate analysis and multivariate logistic regression model were used to analyze the influencing factors of sudden deafness.In addition,ROC curve was drawn to evaluate the predictive value of multivariate logistic regression model for sudden deafness.Results Among the 200 patients with sudden deafness,168 patients had tinnitus symptoms,90 patients had ear fullness,35 patients had periauricular numbness,41 patients had vertigo,37 had nausea,and 29 had vomiting.There were 214 affected ears,of which 186 were unilateral.From the aspect of hearing curve analysis,the proportion of flat descent type and total deafness type was relatively high,which reached 35.05％and 33.18％respectively.In terms of the degree of hearing loss,severe and extremely severe accounted for a relatively high proportion,reaching 40.19％and 30.84％,respectively.The results of univariate analysis showed that there were statistically significant differences in homocysteine(Hey),recent cold history,sleep disorders,cerebrovascular disease,diabetes,and smoking history between the two groups(P＜0.05).Multivariate binary logistic regression analysis showed that increased Hey level(β=0.045,OR=1.046,95％CI:1.015-1.076),cerebrovascular disease(β=1.094,OR=2.987,95％CI:1.629-5.476),diabetes(β=1.285,OR=3.615,95％CI:1.848-7.070),sleep disorders(β=0.878,OR=2.406,95％CI:1.268-4.560)and recent cold his-tory(β=1.361,OR=3.899,95％CI:2.116-7.182)were independent risk factors for sudden deafness(P＜0.05).ROC analy-sis showed that the sensitivity of the model was 75.0％,the specificity was 63.5％,the Youden index was 0.385,and the AUC value was 0.744(95％CI:0.696-0.793)(P＜0.001).Conclusion Most patients with sudden deafness are unilateral onset,and the clinical symptoms are often characterized by hearing loss,ear fullness,tinnitus,vertigo,etc.The risk factors include increased Hey level,recent cold history,sleep disorders,cerebrovascular diseases,diabetes,etc.In clinical practice,target-ed prevention and treatment strategies should be formulated according to the influencing factors of the disease to effectively reduce the risk of the disease.