阿利西尤单抗对介入术后老年冠心病患者心功能及冠脉微循环的影响OA
Effects of Alirocumab on cardiac function and coronary microcirculation in elderly patients with coronary heart disease after percutaneous coronary intervention
目的 探讨阿利西尤单抗对介入术后老年冠心病患者心功能及冠脉微循环的影响.方法 选取2023年2月至2025年9月遵义医科大学附属医院收治的86例老年冠心病患者作为研究对象,按照随机数字表法分为对照组(43例)和观察组(43例),对照组介入术后采用阿托伐他汀钙治疗,观察组基于对照组用药条件采用阿利西尤单抗治疗.比较两组的脂代谢指标、心功能、冠脉微循环、炎症标志物及不良反应.结果 治疗后,观察组三酰甘油、总胆固醇及低密度脂蛋白胆固醇均低于对照组,差异有统计学意义(P<0.05).治疗后,观察组左室射血分数高于对照组,左室舒张末期及收缩末期内径低于对照组,差异有统计学意义(P<0.05).治疗后,观察组静息、充血冠脉血流速度与冠脉血流速度储备高于对照组,差异有统计学意义(P<0.05).治疗后,观察组肿瘤坏死因子-α、超敏C反应蛋白值低于对照组,差异有统计学意义(P<0.05).两组的不良反应总发生率比较,差异无统计学意义(P>0.05).结论 阿利西尤单抗辅助介入手术治疗能够有效调节老年冠心病患者的机体脂代谢状况,改善患者的心功能,促进冠脉微循环恢复,加快机体炎症标志物清除,并避免增加不良反应发生率.
Objective To explore the effects of Alirocumab on cardiac function and coronary microcirculation in elderly pa-tients with coronary heart disease after interventional therapy.Methods A total of 86 elderly patients with coronary heart disease admitted to the Affiliated Hospital of Zunyi Medical University from February 2023 to September 2025 were selected as the research subjects,they were divided into the control group(43 cases)and the observation group(43 cases)according to the random number table method.The control group was treated with atorvastatin calcium after interventional therapy,while the observation group was treated with Alirocumab based on the medication conditions of the control group.The lipid metabolism indicators,cardiac function,coronary microcirculation,inflammatory markers,and adverse reactions of the two groups were compared.Results After treatment,the triglyceride,total cholesterol,and low-density lipoprotein cholesterol levels in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the left ventricular ejection fraction in the observation group was higher than that in the control group,and the left ventricular end-diastolic and end-systolic diameters were lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the resting and hyperemic coronary blood flow velocity and coronary flow reserve in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the tumor necrosis factor-α and high-sensitivity C-reactive protein lev-els in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Alirocumab-assisted interventional therapy can effectively regulate lipid metabolism in elderly patients with coronary heart disease,improve cardiac function,promote the recovery of coronary microcirculation,accelerate the clearance of inflammatory markers,and avoid increasing the incidence of adverse reactions.
王希;曾羽
遵义医科大学附属医院心血管内科,贵州遵义 563000遵义医科大学附属医院心血管内科,贵州遵义 563000
医药卫生
冠心病阿利西尤单抗介入手术心功能冠脉微循环
Coronary heart diseaseAlirocumabInterventional surgeryCardiac functionCoronary microcirculation
《中国当代医药》 2026 (22)
51-54,4
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