非ST段抬高型急性冠状动脉综合征患者血清微小RNA-143、微小RNA-155对经皮冠脉介入术后再狭窄的预测价值OA
Predictive value of serum microRNA-143 and microRNA-155 on resteno-sis after percutaneous coronary intervention in patients with non-ST-seg-ment elevation acute coronary syndrome
目的 分析非ST段抬高型急性冠状动脉综合征(NSTE-ACS)患者血清微小RNA-143(miR-143)、微小RNA-155(miR-155)对经皮冠脉介入术(PCI)后再狭窄的预测价值.方法 回顾性分析2020年6月至2025年8月于遵义医科大学附属医院治疗的314例NSTE-ACS患者的临床资料,根据PCI后6个月内是否出现支架内再狭窄(ISR)分为狭窄组(n=53)与未狭窄组(n=261),比较两组患者的临床资料和血清miR-143、miR-155水平,采用ROC曲线分析血清miR-143、miR-155对PCI后ISR的预测价值,采用多因素logistic回归模型分析PCI后ISR的影响因素.结果 单因素分析结果显示,两组患者的年龄、糖尿病史、支架长度、支架数目、支架直径、美国心脏病学院(ACC)/美国心脏协会(AHA)冠状动脉病变分型,以及支架膨胀率比较,差异有统计学意义(P＜0.05);狭窄组的miR-143、miR-155水平均高于未狭窄组,差异有统计学意义(P＜0.05).多因素logistic回归分析结果显示,糖尿病史、支架长度、支架数目、支架直径、ACC/AHA冠状动脉病变分型、miR-143、miR-155是PCI后ISR的独立危险因素,支架膨胀率是PCI后ISR的独立保护因素(P＜0.05).血清miR-143、miR-155预测PCI后ISR的AUC分别为0.874、0.892,敏感度分别为90.57％、90.57％,特异度分别为70.88％、75.10％.结论 血清miR-143、miR-155水平在NSTE-ACS患者PCI后ISR的预测中具有重要价值.糖尿病史、支架长度、支架数目、支架直径、ACC/AHA冠状动脉病变分型、支架膨胀率是PCI后ISR的独立影响因素,上述指标可作为临床评估PCI后ISR风险的有效指标,为早期干预和治疗提供依据.
Objective To analyze the predictive value of serum microRNA-143(miR-143)and microRNA-155(miR-155)on restenosis after percutaneous coronary intervention(PCI)in patients with non-ST-segment elevation acute coronary syndrome(NSTE-ACS).Methods The clinical data of 314 patients with NSTE-ACS treated in the Affiliated Hospital of Zunyi Medical University from June 2020 to August 2025 were retrospectively analyzed.According to the presence or absence of in-stent restenosis(ISR)within 6 months after PCI,the patients were divided into stenosis group(n=53)and non-stenosis group(n=261).The clinical data and serum levels of miR-143 and miR-155 were compared between the two groups.The ROC curve was used to analyze the predictive value of serum miR-143 and miR-155 for ISR after PCI.The multivariate logistic regression model was used to analyze the influencing factors of ISR after PCI.Results Univariate analy-sis showed that there were significant differences in age,history of diabetes,stent length,stent number,stent diameter,American College of Cardiology(ACC)/American Heart Association(AHA)classification of coronary lesions,and stent expansion rate between the two groups(P＜0.05).The levels of miR-143 and miR-155 in the stenosis group were higher than those in the non-stenosis group,and the differences were statistically significant(P＜0.05).Multivariate logistic re-gression analysis showed that the history of diabetes,stent length,stent number,stent diameter,ACC/AHA classification of coronary lesions,miR-143 and miR-155 were independent risk factors for ISR after PCI,and stent expansion rate was an independent protective factor for ISR after PCI(P＜0.05).The AUCs of serum miR-143 and miR-155 in predicting ISR af-ter PCI were 0.874 and 0.892,the sensitivities were 90.57％and 90.57％,and the specificities were 70.88％and 75.10％,respectively.Conclusion Serum levels of miR-143 and miR-155 have important value in predicting ISR in NSTE-ACS patients after PCI.Diabetes history,stent length,stent number,stent diameter,ACC/AHA classification of coronary lesions and stent expansion rate are independent influencing factors of ISR after PCI.The above indicators can be used as effective indicators for clinical assessment of ISR risk after PCI and provide a basis for early intervention and treatment.
曾羽;胡姗
遵义医科大学附属医院心内科,贵州遵义 563000遵义医科大学附属医院心内科,贵州遵义 563000
医药卫生
非ST段抬高型急性冠状动脉综合征经皮冠脉介入术支架内再狭窄生物标志物
Non-ST-segment elevation acute coronary syndromePercutaneous coronary interventionIn-stent restenosisBiomarkers
《中国当代医药》 2026 (23)
48-52,5
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