抑郁对次极量运动后心率变异性和心率恢复的影响OA

Objective To investigate the effects of depression on heart rate variability(HRV)and heart rate recovery(HRR)after submaximal exercise.Methods A total of 48 participants who underwent cardiopulmonary exercise testing at the Department of Rehabilitation Medicine,the Affiliated Brain Hospital of Nanjing Medical University from January 2020 to January 2024 were ret‐rospectively enrolled.Among them,25 patients diagnosed with major depressive disorder were assigned to the case group,and 23 in‐dividuals without prior history of anxiety,depression,or other psychiatric disorders and with Hamilton Depression Rating Scale-17(HAMD-17)score≤7 were assigned to the control group.Both groups performed submaximal cycle ergometer exercise tests.Post-exer‐cise HRV,measured as the root mean square of successive differences(RMSSD),and HRR indices at the 1st,2nd,and 3rd minutes of recovery(HRR1,HRR2,HRR3)were collected and compared between the two groups.Data from both groups were combined,and univariate and multivariate linear regression analyses(adjusted for sex,age,and body mass index)were performed to assess the association between depression and autonomic nervous function.Results The HAMD-17 score in the case group was signifi‐cantly higher than that in the control group(P<0.05).The RMSSD,HRR1,HRR2,and HRR3 measured after submaximal exercise were significantly lower in the case group compared with the control group(P<0.05).Univariate and multivariate regression analy‐ses showed that the HAMD-17 score was negatively correlated with post-exercise RMSSD,HRR1,HRR2,and HRR3(P<0.05),and these associations remained statistically significant after adjusting for confounding factors(P<0.05).Conclusion Depression attenuates parasympathetic activity after submaximal exercise,leading to delayed autonomic recovery.Additionally,HAMD-17 score is negatively correlated with post-exercise HRV and HRR indices.