Hippo-YAP信号通路与神经胶质瘤OA

The Hippo-YAP signaling pathway is a highly evolutionarily conserved signaling cascade that plays a critical role in regulating tissue homeostasis and tumor progression.Its aberrant activation is closely associated with malignant progression of glioma.Glioma is one of the most common intracranial malignant tumors in humans,accounting for approximately 80%of malignant brain tumors.Despite advances in surgical resection and adjuvant chemoradiotherapy,patients continue to experience high postoperative recurrence rates and poor prognosis.In glioma,the downstream effectors of the Hippo-YAP signaling pathway,Yes-associated protein(YAP)and transcriptional co‑activator with PDZ‑binding motif(TAZ),are highly expressed and exert oncogenic functions.Meanwhile,the expression levels of the core kinases mammalian sterile‑20‑like kinase 1/2(MST1/2)and large tumor suppressor kinase 1/2(LATS1/2)are decreased.These components regulate YAP/TAZ activity and contribute to malignant progression of glioma.In addition,the Hippo-YAP signaling pathway participates in remodeling the glioma immune microenvironment and maintaining the stemness and phenotypic heterogeneity of glioma stem cells.Following the introduction of the new World Health Organization classification of central nervous system tumors,substantial differences in YAP/TAZ activity have been identified among molecular subtypes of glioma.Targeting the Hippo-YAP signaling pathway may reverse chemoresistance and suppress malignant phenotypes of glioma.Further investigation of the regulatory mechanisms of YAP/TAZ in glioma and optimization of translational therapeutic strategies may provide new directions for improving clinical outcomes and survival of patients with glioma.