TRPS1在结节性筋膜炎中的表达及意义OA

Objective:Nodular fasciitis(NF)is a benign reactive myofibroblastic proliferative lesion.Because of the variable morphology of its spindle cells,NF can be confused with low-grade malignant soft tissue tumors.Although USP6 gene rearrangement is an important molecular feature of NF,routine diagnosis still requires integrated assessment of morphology and immunophenotype.Trichorhinophalangeal syndrome type 1 protein(TRPS1),a commonly used marker for breast carcinoma,has recently been found to be expressed in some non-breast tumors and reactive stromal cells;however,its expression characteristics in NF remain unclear.This study aims to investigate the expression pattern of TRPS1 in NF and its clinicopathological significance. Methods:Twenty patients with NF diagnosed at the First Affiliated Hospital of Soochow University between December 2021 and January 2026 and confirmed by fluorescence in situ hybridization(FISH)for USP6 rearrangement were included.TRPS1 expression was detected by immunohistochemistry,and its associations with clinicopathological parameters were analyzed. Results:TRPS1 positivity was observed in 17 of 20 NF cases(85%),with staining predominantly localized to the nuclei of spindle cells.Positive cases mainly showed moderate-to-strong staining intensity,and diffuse staining was observed in some cases.According to grouping based on the median immunohistochemical score,patients in the TRPS1 high-expression group were younger than those in the low-expression group,with a statistically significant difference(P=0.025).No statistically significant differences were observed between the 2 groups in maximum tumor diameter,disease duration,Ki-67 proliferation index,or sex(all P>0.05). Conclusion:TRPS1 expression is relatively common in NF,and some cases may show high-level expression,suggesting that TRPS1 can be expressed in reactive myofibroblastic lesions and may reflect an activated lesional state.Whether TRPS1 expression is associated with USP6 gene rearrangement requires further investigation.TRPS1 is not a tumor-specific marker,and its expression in spindle-cell lesions of soft tissue should be interpreted with caution to avoid misdiagnosis.