推拿疗法治疗失眠的临床证据及作用机制研究OA

By reviewing clinical studies and experimental literature on Tuina therapy for insomnia in recent years,this paper provides a systematic review from two aspects:clinical evidence and mechanism of action.Clinical studies have shown that Tuina therapy for insomnia offers several advantages,including mild painful stimulation,comfortable sensation,high acceptability,strong patient compliance,and no dependence.Mechanistic studies have shown that Tuina exerts its therapeutic effects on insomnia by modulating central neurotransmitters(such as 5-hydroxytryptamine and γ-aminobutyric acid),influencing bioactive cytokines(such as interleukin-6 and tumor necrosis factor-α),and regulating the function of the"brain-gut axis."Among these,the mechanism by which Tuina treats insomnia through brain-gut axis regulation has emerged as a research hotspot in recent years.