国医大师姚希贤治疗慢性乙型病毒性肝炎肝硬化临证经验及用药规律探析OA

Objective:To summarize the clinical experience and prescription medication rules of National TCM Master Yao Xixian in the treatment of chronic hepatitis B virus-related cirrhosis using data mining methods.Methods:This study collected the prescriptions of Yao Xixian in treating chronic hepatitis B cirrhosis and established a database using Microsoft Excel.With the aid of software including IBM SPSS Statistics 25.0 and SPSS Modeler 18.0,frequency analysis,clustering analysis,and association analysis were performed to systematically investigate the medication rules underlying Yao Xixian's formula composition in the treatment of chronic hepatitis B cirrhosis.Results:A total of 115 prescriptions for the treatment of chronic hepatitis B cirrhosis were included,involving 151 herbal medicines.The high-frequency medicines were stir-fried Baizhu(fried Atractylodes macrocephala),Fuling(Poria),stir-fried Jineijin(stir-fried Endothelium Corneum Gigeriae Galli),Danshen(Salvia miltiorrhiza),and Huangqi(Astragalus membranaceus),among others.In terms of flavor,the medicines were predominantly bitter,pungent,and sweet;in terms of property,they were mainly warm,cold,and neutral;and in terms of meridian tropism,they chiefly entered the spleen,lung,stomach,and liver meridians.Cluster analysis revealed four major herbal combinations,which jointly exerted the effects of regulating Qi and activating blood,supplementing Qi and resolving stasis.Conclusion:Yao Xixian establishes the pathogenesis of chronic hepatitis B cirrhosis on the basis of the"blood stasis syndrome,"and adopts"activating blood to resolve stasis,soothing the liver to regulate Qi,and invigorating the spleen to supplement Qi"as the fundamental therapeutic principles.In clinical medication,he pays close attention to harmonizing Qi and blood,safeguarding the liver and spleen,concurrently regulating the five zang organs,employing the method of pungent-opening and bitter-descending,and combining clear-dispersing with warm-tonifying approaches.This provides an important theoretical reference for the traditional Chinese medicine treatment of chronic hepatitis B cirrhosis.