基于"从脾论治"探讨肠道菌群与类风湿关节炎的相关性OA

Using the theoretical framework of"treatment from the spleen,"this paper systematically reviews the mechanisms by which gut microbiota dysbiosis induces the onset of rheumatoid arthritis(RA),including the activation of inflammatory responses,increased intestinal permeability,and the induction of post-translational modifications of host proteins.Furthermore,the close association between gut microbiota and the"spleen"in TCM is elucidated from both the physiological functions and pathological mechanisms,suggesting that they share similarities in terms of nutrient absorption,immune defense,and disease development.Based on the core pathogenesis of"spleen deficiency with dampness excess"in RA,treatment from the spleen may exert its therapeutic effects by modulating the gut microbiota.