狭窄型克罗恩病的临床管理和外科干预OA
Clinical management and surgical intervention for stricturing Crohn's disease
克罗恩病的病程呈复发—缓解交替,在长期的透壁性炎症刺激下,患者的肠道会出现结构性损伤.狭窄是克罗恩病的严重并发症,而且狭窄型克罗恩病患者在克罗恩病患者中占有一定的比例,临床中对于此类型患者的管理方案呈阶梯化,外科干预是部分患者最终需要接受的治疗方式.本文结合文献报道,以狭窄型克罗恩病的病理机制和临床分型为切入点,概述对于患者的阶梯化管理理念,侧重围绕外科手术的实施原则与狭窄成形术和肠吻合术在临床中的应用进行陈述,以及分享笔者团队所在中心的临床实践经验.
Crohn's disease follows a relapsing-remitting course.Under long-standing transmural inflammation,patients develop structural bowel damage.Stricture is a severe complication of Crohn's disease,affecting a considerable proportion of patients.Clinical management of these patients follows a stepwise approach,with surgical intervention being the ultimate treatment modality for some cases.Drawing on the published literature,this review begins with the pathological mechanisms and clinical classification of stricturing Crohn's disease,outlines the concept of stepwise disease management,focuses on the principles of surgical intervention and the clinical application of strictureplasty and intestinal anastomotic techniques,and shares the practical experience of our center.
蔡钊阳;屠倩文;张梦婷;丁召
武汉大学中南医院结直肠肛门外科(炎症性肠病外科诊疗中心) 湖北 武汉 430071武汉大学中南医院结直肠肛门外科(炎症性肠病外科诊疗中心) 湖北 武汉 430071武汉大学中南医院结直肠肛门外科(炎症性肠病外科诊疗中心) 湖北 武汉 430071武汉大学中南医院结直肠肛门外科(炎症性肠病外科诊疗中心) 湖北 武汉 430071
医药卫生
克罗恩病肠道狭窄临床管理外科干预狭窄成形术肠吻合术
Crohn's diseaseintestinal strictureclinical managementsurgical interventionstrictureplastyintestinal anastomosis
《结直肠肛门外科》 2026 (4)
352-358,7
吴阶平医学基金会临床科研专项资助基金(320.6750.2025-11-7)
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