克罗恩病的外科管理:现状与挑战OA

Crohn's disease is a chronic,transmural,and progressive inflammatory bowel disease characterized by cumulative structural damage and a high rate of recurrence.Although biologic agents have achieved considerable success in controlling inflammation,a substantial proportion of patients still require surgical intervention.In recent years,the treat-to-target concept—emphasizing objective control of inflammation and prevention of structural damage—has been progressively incorporated into the comprehensive management framework for Crohn's disease.Accordingly,surgery should no longer be viewed simply as a last resort after medical treatment failure.From the perspective of treat-to-target,this review evaluates the current status and challenges of surgical management in Crohn's disease,explores optimization and individualization of treatment decisions,and analyzes other important clinical management approaches and strategies.