基于伏邪致痹理论探讨痛风饮维持痛风缓解期湿浊内蕴证患者尿酸稳定及改善内脏代谢的临床研究OA

Objective To observe the clinical efficacy of Tongfengyin on maintaining uric acid stability,improving visceral metabolism,and reducing traditional Chinese medicine dampness-heat syndrome scores in patients with dampness-turbidity internal retention syndrome during the remission stage of gout.Methods A total of 68 patients with gout in the remission phase and dampness-turbidity internal retention syndrome,who were treated at the outpatient clinics and inpatient wards of the department of Rheumatology and Endocrinology at the Second People's Hospital of Fujian University of Traditional Chinese Medicine,from March 2025 to December 2025,were enrolled.They were randomly divided into the experimental and control groups using the random number table method,with 34 patients in each group.The control group received febuxostat treatment,whereas the experimental group received Tongfengyin in addition to febuxostat,both for 12 consecutive weeks.The serum uric acid levels,visceral fat area,brachial-ankle pulse wave velocity,traditional Chinese medicine dampness-heat syndrome scores,as well as liver and renal function,were observed and compared between the two groups before and after treatment.Results Ultimately,31 patients in each group completed the study.After 12 weeks of treatment,the serum uric acid level in the experimental group decreased significantly compared with that before treatment(P<0.05)and was also lower than that in the control group(P<0.05).The boxplot result showed that the entire box fell almost completely within the stability range.After 12 weeks of treatment,the visceral fat area in both groups decreased compared with that before treatment(P<0.05).After 12 weeks of treatment,the brachial-ankle pulse wave velocity of both lower limbs and the traditional Chinese medicine dampness-heat syndrome scores in the experimental group decreased significantly compared with those before treatment(P<0.05)and were also lower than those in the control group(P<0.05).Conclusion The addition of Tongfengyin to febuxostat therapy can expel latent pathogens,thereby regulating serum uric acid levels,maintaining uric acid stability,improving brachial-ankle pulse wave velocity of both lower limbs,and alleviating clinical symptoms in patients during the remission phase of gout,achieving better therapeutic outcomes compared with Western medicine treatment alone.