基于"肠道菌群"探讨"从脾肾论治"痛风性肾病的中西医内涵OA

Gouty nephropathy is a disease primarily characterized by renal damage resulting from abnormalities in uric acid production and/or excretion and the deposition of urate crystals.Traditional Chinese Medicine(TCM)pos-its that the pathogenesis of gouty nephropathy involves a root cause of dual deficiency of the spleen and kidney,and a manifestation characterized by the obstruction of damp-turbidity and blood stasis;therefore,"regulating the spleen and kidney,dispelling dampness,invigorating blood circulation,and eliminating turbidity"constitutes a key thera-peutic principle.Furthermore,the integration of TCM theory with modern research has revealed significant similarities between the gut micro-iota and the spleen and kidney in terms of both location and function.Consequently,this paper focuses on the gut microbiota and the therapeutic approach of"treating based on the spleen and kidney".It explores in depth the scientific basis and potential mechanisms of treating gouty nephropathy by regulating the spleen and kidney to improve the state of the gut microbiota,thereby offering new perspectives for the prevention and treatment of gouty nephropathy using TCM.