基于"浊阴"探讨狼疮性肾炎发病机制及中医证治规律研究OA

Lupus nephritis(LN)is the most common and severe complication of systemic lupus erythematosus(SLE)associated with a poor prognosis;its pathogenesis is complex,and current treatments offer limited efficacy and signifi-cant adverse effects.In Traditional Chinese Medicine(TCM),LN is typically categorized as a syndrome characterized by"root deficiency and branch excess".Traditional treatment approaches focusing on damp-heat,phlegm-turbidity,and stasis-toxin have struggled to systematically explain the concurrent nature of recurrent immune-inflammatory ac-tivation and structural renal damage.By integrating the clinical manifestations and modern pathological mechanisms of LN with relevant theories from the"Huangdi Neijing"(Inner Canon of the Yellow Emperor),this paper introduces the concept of"Zhuo Yin"to the pathogenesis.It proposes a new understanding of LN pathogenesis characterized by the"interlocking of turbid yin and stasis-toxin",positing that spleen-kidney deficiency and the failure of yin to generate clarity constitute the root cause,while the interlocking of damp-turbidity,phlegm-fluid,blood stasis,and toxic patho-gens runs through the entire course of the disease.Based on this framework,the paper outlines a therapeutic strategy that prioritizes nourishing Yin to generate clarity and transforming turbidity to restore clarity,while simultaneously promoting diuresis,invigorating blood circulation,and clearing heat and toxins,aiming to provide a reference for the TCM syndrome differentiation and treatment of LN.