首页|期刊导航|中医临床研究|消化道癌症与舌象及舌面菌群微环境关联性的研究进展

消化道癌症与舌象及舌面菌群微环境关联性的研究进展OA

Research progress on the correlation between gastrointestinal cancers,tongue appearance,and tongue surface microbiome

中文摘要英文摘要

在现有对消化道癌症患者舌象证素的临床研究中,患者的舌象证素与健康个体存在明显差异,其差异在舌苔方面尤为突出.舌面细菌与舌苔存在密切的关联,影响舌证素的最直接因素是舌面原有的微生物环境稳态被打破,造成舌面菌群的种群数量、结构、分布位置发生变化.就消化道癌症而言,其可以通过影响口腔及舌面的理化环境、舌表面细胞脱落情况、免疫活性及炎性浸润情况、口腔菌群结构等因素造成舌表面菌群生存微环境的长期稳定变化,导致舌象证素的变化.探究消化道癌症影响下舌面菌群生存微环境的改变,有助于明确癌病患者病理舌象产生的机制,充实中医舌诊的现代理论依据.口腔中一些癌症相关菌群可以作为潜在的生物标志物,为肿瘤的三级预防、临床疗效与预后评估提供新的客观指标.

In the clinical research on the tongue image syndrome elements of patients with digestive tract cancer,there are significant differences between the tongue image syndrome elements of patients and those of healthy individuals,with the differences being particularly prominent in the tongue coating.There is a close relationship between tongue surface bacteria and tongue coating.The most direct factor causing changes in tongue syndrome elements is the disruption of the original microbial environment homeostasis on the tongue surface,resulting in changes in the distribution of tongue surface flora in terms of abundance,structure,and location.Regarding digestive tract cancer,it can cause long-term stable changes in the survival microecology of tongue surface flora by influencing factors such as the physical and chemical environment of the oral cavity and tongue surface,the shedding of tongue surface cells,immune activity and inflammatory infiltration,and the structure of oral flora,thereby causing changes in tongue image syndrome elements.Exploring the changes in the living microenvironment of the tongue microbiota under the influence of gastrointestinal system cancers helps to clarify the mechanisms behind the pathological tongue signs in cancer patients and improve the modern theoretical basis of traditional Chinese tongue diagnosis.Some cancer-related microbes in the oral cavity can serve as potential biomarkers,providing new objective indicators for tertiary prevention of tumors,clinical efficacy,and prognosis assessment.

李骏蛟;沈卫星

南京中医药大学附属医院/江苏省中医院,江苏 南京,210000南京中医药大学第一临床医学院,江苏 南京,210000

医药卫生

舌象消化道癌症口腔菌群微环境舌面菌群中医证素

Tongue imageGastrointestinal system cancerOral microflora microenvironmentTongue surface microfloraTraditional Chinese medicine syndrome element

《中医临床研究》 2026 (20)

25-29,5

10.3969/j.issn.1674-7860.2026.20.004

评论