基于随机对照试验的一项关于益生菌对血压影响的Meta分析OA

Objective To systematically review the relationship between probiotics and blood pressure.Methods The PubMed(MEDLINE),Embase,Web of Science,Cochrane Library,China National Knowledge Infrastructure,Wanfang Data Knowledge Service Platform were searched to collect randomized controlled trials included the relationship between probiotics and blood pressure,with the search period ranging from database establishment to February 1,2026.Two researchers independently screened the literature,extracted data,and assessed the risk of bias in the included studies,followed by a Meta-analysis using RevMan 5.4.1 software.Results A total of 23 articles were included.Meta-analysis results showed that using probiotics preparations can significantly reduce diastolic pressure compared with control group.Subgroup analysis showed that whether the intervention duration was greater than or equal to 8 weeks might be a source of heterogeneity,while whether it was a single strain or whether it is a hypertensive population are not a factor affecting heterogeneity.Conclusion Probiotics intervention has a positive effect on controlling blood pressure,especially diastolic blood pressure.Due to the limitations in the number and quality of included studies,the above conclusions still need to be verified by more high-quality research.