早发型结直肠癌临床特点与危险因素分析OA

Objective To explore the clinical characteristics and related risk factors of early-onset colorectal cancer(EOCRC).Methods A retrospective single center case-control study was conducted,including 200 colorectal cancer patients who underwent colonoscopy and were diagnosed at Xinyu People's Hospital from January 2023 to December 2025.The patients were divided into EOCRC group(76 cases)and late-onset colorectal cancer(LOCRC)group(124 cases)according to their age.Compare two sets of clinical data to clarify the clinical characteristics of EOCRC,incorporate statistically significant clinical features into a multivariate Logistic regression model,and analyze the risk factors for EOCRC occurrence.Results Compared with LOCRC group,patients in EOCRC group had a later stage,higher body mass index(BMI),initial symptoms of constipation,nerve invasion,vascular invasion,smoking history,and a higher proportion of ulcer type;The proportion of diabetes history,hypertension history,family history of gastrointestinal tumor and colon polyp was lower(P<0.05);Multivariate Logistic regression analysis showed that western diet pattern,high BMI,smoking history and irregular work and rest were the high risk factors for EOCRC(P<0.05),while hypertension,diabetes and colon polyps were the risk factors for LOCRC(P<0.05).Conclusion EOCRC has clinical features of late tumor staging and stronger invasiveness,and its occurrence is closely related to factors such as high BMI and smoking.