预充氧策略对非机械通气危重患者院内转运期间氧合稳定性及应激反应的影响OA

Objective To evaluate the effects of preoxygenation strategies on oxygenation stability and stress response in non-mechanically ventilated critically ill patients during intra-hospital transport.Methods A total of 80 critically ill patients transported within Taizhou Hospital of Zhejiang Province from January 2022 to January 2025 were enrolled as study subjects.They were divided into control group(n=40)and study group(n=40)based on the actual pre-oxygenation method employed during transportation.The control group received conventional nasal cannula pre-oxygenation,while the study group received standardized non-rebreather(NRB)pre-oxygenation.Vital signs indices,stress responses,and clinical outcomes were monitored at three time points:the lowest point during transportation(T1),immediately after transportation(T2),and before transportation(T0).Results At T1 and T2,oxygen saturation and partial pressure of arterial oxygen/fraction of inspired oxygen ratio were higher,along with respiratory rate and heart rate(HR)were lower in study group compared to the control group(P<0.05).Incidence of hypoxemia,HR fluctuation>20%and blood pressure fluctuations>20%,and rate-pressure product were lower in study group compared to control group(P<0.05).Although the preoxygenation preparation time was longer in study group,the preoxygenation qualification rate was significantly higher in study group(P<0.001).Incidence of new-onset organ dysfunction was significantly lower in study group compared to control group.Conclusion Standardized NRB preoxygenation effectively maintains oxygenation stability,reduces stress response,and the risk of new-onset organ dysfunction in non-mechanically ventilated patients during intra-hospital transport.