小菜蛾对Bt Cry1Ac杀虫蛋白抗性的遗传与信号调控机制OA

Cruciferous vegetables are among the most important vegetable crops in China.They are not only a core component of the national vegetable supply system but also play a crucial role in seed indus-try revitalization,rural development,and functional agriculture.The diamondback moth Plutella xylo-stella is a major pest of cruciferous vegetables and causes substantial economic losses to agricultural production each year.Bacillus thuringiensis(Bt)produces a variety of insecticidal proteins,including Cry1Ac,which have been widely used for the control of P.xylostella because of their high efficacy,target specificity,and environmental safety.However,the evolution of resistance to the Bt Cry1Ac toxin in P.xylostella has greatly reduced the effectiveness of Bt-based pest control.This review summarizes the resistance mechanisms of P.xylostella to Bt Cry1Ac toxin,with particular emphasis on resistance evolution mediated by alterations in midgut receptors and signaling pathways.Future research direc-tions are also discussed,highlighting the need to integrate modern genetics,molecular biology,and multi-omics approaches to further elucidate the molecular mechanisms underlying Bt resistance.