炎症细胞因子与甲状旁腺激素因果关联的孟德尔随机化研究OA

Objective To identify the causal associations between serum inflammatory cytokines and parathy-roid hormone(PTH)levels using bidirectional Mendelian randomization(MR)analysis.Methods A bidirectional MR design was employed,utilizing single nucleotide polymorphisms(SNPs)as instrumental variables to assess the causal effects of serum inflammatory cytokines on PTH levels and vice versa.Publicly available genotype data were ana-lyzed using inverse-variance weighted(IVW),MR Egger,simple mode,enhanced mode and weighted median meth-ods.Sensitivity analyses were conducted to evaluate the reliability of the results.Results Forward MR analysis showed a significant negative association between osteoprotegerin(OPG)and PTH levels(OR=0.426,95%CI:0.201-0.905,P=0.026).Reverse MR analysis revealed a significant negative association between PTH and tumor necrosis factor ligand superfamily member 14(TNFSF14)levels(OR=0.963,95%CI:0.933-0.995,P=0.022),and a significant positive association between PTH and interleukin-17C(IL-17C)levels(OR=1.039,95%CI:1.004-1.075,P=0.031).No heterogeneity or pleiotropy was detected in sensitivity analyses.Conclusion There is a nega-tive correlation between OPG and PTH,while the level of PTH is negatively correlated with the level of TNFSF14 and positively correlated with IL-17C.