天然产物抑制TLR4/NF-κB信号通路抗肝纤维化的研究进展OA
Research progress on natural products inhibiting TLR4/NF-κB signaling pathway against liver fibrosis
肝纤维化是慢性肝损伤修复过程中肝星状细胞(he-patic stellate cells,HSCs)异常活化及细胞外基质(extracellu-lar matrix,ECM)过度沉积的病理结果,其核心机制涉及TLR4/NF-κB信号通路.天然产物可以通过调控TLR4/NF-κB通路发挥抗纤维化作用.该文综述了天然产物抑制TLR4/NF-κB信号通路抗肝纤维化的研究进展,同时,还讨论了天然产物在临床应用中的前景和挑战,为未来研究抗肝纤维化药物及开发新型保肝药提供参考.
Hepatic fibrosis is a pathological outcome of abnor-mal activation of hepatic stellate cells(HSCs)and excessive de-position of extracellular matrix(ECM)during the repair process of chronic liver injury.Its core mechanism involves the TLR4/NF-κB signaling pathway.Natural products can exert anti-fibrotic effects by regulating the TLR4/NF-κB signaling path-way.This article reviews the research progress of natural prod-ucts in inhibiting the TLR4/NF-κB pathway to prevent liver fi-brosis.Meanwhile,it also discusses the prospects and chal-lenges of natural products in clinical application,providing ref-erences for future research on anti-fibrotic drugs and the devel-opment of new hepatoprotective agents.
林维嘉;韦璐琳;何乃焕;覃著文;丘岳;韦锦斌
广西医科大学药学院药理学教研室广西医科大学药学院药理学教研室广西医科大学药学院药理学教研室广西医科大学药学院药理学教研室广西医科大学第一附属医院药学部,广西南宁 530021广西医科大学药学院药理学教研室
医药卫生
肝纤维化TLR4/NF-κB信号通路天然产物生物碱黄酮类化合物萜类化合物
hepatic fibrosisTLR4/NF-κB signaling pathwaynatural productsalkaloidsflavonoidsterpenoids
《中国药理学通报》 2026 (9)
1632-1635,4
国家自然科学基金资助项目(No 82360820)
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