谷氨酰胺代谢与氨死亡:机制及治疗新策略OA
Glutamine metabolism and ammonia-induced cell death:mechanisms and novel therapeutic strategies
氨一直以来被认为是肝脏代谢的有毒废物.然而,近年来医学领域出现了一种新的细胞死亡形式,氨诱导的细胞死亡(ammonia-induced cell death,AICD),这为肿瘤免疫疗法提供了新视角.该综述系统性阐述了 AICD的发现历程与分子机制、分析了靶向谷氨酰胺(glutamine,Gin)代谢轴的抗肿瘤潜力、探讨了靶向氨代谢增强免疫治疗的新型联合策略,并分析了该新兴领域面临的挑战与局限,旨在为癌症治疗提供新思路.
Ammonia has traditionally been viewed as a toxic by-product of hepatic metabolism.However,the recent discovery of ammonia-induced cell death(AICD)-a distinct mode of regu-lated cell death-has challenged this dogma and unveiled new therapeutic opportunities in cancer immunotherapy.Herein,we delineate the molecular underpinnings of AICD and its meta-bolic interplay with glutamine metabolism,discuss glutamine-targeted anti-cancer strategies,and explore ammonia-metabo lism-directed combinatorial immunotherapy approaches.We further critically appraise the current obstacles and translational hurdles facing this nascent field.
秦晴艳;蔡诗坤;谭亲友
桂林医科大学第一附属医院临床药学与临床药理学教研室,广西桂林 541001||桂林医科大学药学院,广西桂林 541199桂林医科大学第一附属医院临床药学与临床药理学教研室,广西桂林 541001||桂林医科大学药学院,广西桂林 541199桂林医科大学第一附属医院临床药学与临床药理学教研室,广西桂林 541001||桂林医科大学药学院,广西桂林 541199||中美健康与疾病脂质研究中心,广西桂林 541001
医药卫生
谷氨酰胺代谢氨死亡抗肿瘤CD8+Teff细胞耐药免疫细胞
glutamine metabolismammonia-induced cell deathantitumorCD8+Teff cellsdrug resistanceimmune cells
《中国药理学通报》 2026 (9)
1620-1625,6
国家自然科学基金资助项目(No 82160765)广西自然科学基金资助项目(No 025JJA140834)
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