神经药理学发展与前沿OA
Developments and frontiers in neuropharmacology
神经药理学聚焦外源性活性物质与神经系统的相互作用,为神经精神疾病诊疗提供重要支撑.该文回顾其发展历程,阐述从递质机制到精准靶点与转化医学的研究进展,探讨神经退行性及精神疾病治疗突破,并针对机制复杂性、血脑屏障及个体差异等挑战,提出多学科融合、精准调控与个体化治疗创新方向.
Neuropharmacology focuses on the interactions be-tween exogenous active substances and the nervous system,pro-viding essential foundations for the diagnosis and treatment of neuropsychiatric disorders.This review traces the development of this field,elucidating research advances from neurotrans mitter-based mechanisms to precision targets and translational medicine.It further explores therapeutic breakthroughs in neu-rodegenerative and psychiatric disorders.Addressing challen ges such as mechanistic complexity,the blood-brain barrier and individual variability,the review proposes innovative directions for multidisciplinary integration,precision regulation and per-sonalized treatment.
郜丹;朱意攀;李林;张兰
首都医科大学宣武医院药学部,北京 100053首都医科大学宣武医院药学部,北京 100053首都医科大学宣武医院药学部,北京 100053首都医科大学宣武医院药学部,北京 100053
医药卫生
神经药理学神经精神疾病药物研发国内研究进展个体化治疗疾病修饰治疗
neuropharmacologyneuropsychiatric disordersdrug discovery and developmentdomestic research progresspersonalized treatmentdisease-modifying therapy
《中国药理学通报》 2026 (9)
1607-1612,6
国家自然科学基金资助项目(No 82574602)
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