脂多糖的生物学功能及其在奶牛子宫内膜炎中的作用机制OA

Dairy bovine endometritis is a common reproductive disorder in postpartum dairy cows.Multiple factors including dystocia,retained placenta,bacterial infection,and improper feeding and management can trigger this disease and further result in reproductive problems such as abnormal estrus and reduced conception rate.Among the various pathogenic factors of endometritis,bacterial infection serves as the primary cause,with Gram-negative bacterial infection being the most prevalent.Lipopolysaccharide,a unique component of the cell wall of Gram-negative bacteria,is one of the key factors contributing to the occurrence of dairy bovine endometritis.In cases of bovine endometritis,lipopolysaccharide initiates a series of signal transduction cascades by specifically binding to Toll-like receptor 4(TLR4)on the surface of host cells,which ultimately induces the activation of immune cells and massive release of cytokines,thereby causing inflammatory damage to the endometrium.This paper therefore reviews the biological functions of lipopolysaccharide and its underlying mechanisms in dairy bovine endometritis,aiming to provide a theoretical reference for exploring efficient prevention and treatment strategies for this disease.