哺乳动物精子铁死亡与精液品质的关系研究进展OA

Ferroptosis is a form of iron-dependent programmed cell death.Iron overload and mitochondrial dysfunction caused by disrupted iron metabolism promote excessive accumulation of lipid peroxides,thereby affecting the structure and function of spermatozoa.The key enzymes of ferroptosis exhibit species-specific subcellular localization in spermatozoa,and these localization differences directly impact spermatozoa antioxidant capacity,reactive oxygen species metabolism,and structural integrity.This article aims to review the triggers of ferroptosis,the species-specific localization of key enzymes,and detection methods,as well as to summarize their relationship with semen quality,providing a theoretical basis for optimizing spermatozoa preservation techniques.