白藜芦醇在精液冷冻保存中的应用及作用机制研究进展OA

Semen cryopreservation is a pivotal step in livestock breeding and an essential strategy for the conservation of genetic resources.However,cryopreservation-induced stress inevitably causes cryodamage to spermatozoa,characterized by structural alterations,physiological dysfunction,and metabolic disturbances,which severely affect semen quality and fertilizing potential.Resveratrol,a naturally occurring polyphenolic compound,exerts diverse biological effects by scavenging free radicals,inhibiting inflammatory responses,and modulating energy metabolism,and has been extensively applied in the context of semen cryopreservation.Nevertheless,the precise protective efficacy and underlying molecular mechanisms of resveratrol during the cryopreservation process have not yet been fully elucidated.This review summarizes the adverse effects of cryopreservation stress on spermatozoa and discusses recent advances in the application and mechanisms of resveratrol in semen cryopreservation,aiming to provide a theoretical foundation for optimizing cryopreservation protocols and developing novel antioxidants and cryoprotective agents for semen preservation.