胰腺癌累及血管精准切除重建技术及评价OA
Precise resection and reconstruction techniques for vascular involvement in pancreatic cancer and their evaluation
胰腺癌确诊时常因血管侵犯而失去直接手术指征.在精准外科理念指导下,可切除性评估应从"解剖学"转向"生物学",从"可切除性"转向"可重建性".需动态评估肿瘤生物学反应以决策最佳手术时机.术前需对受累血管进行精准评估,以规划个体化切除重建策略.静脉切除重建技术已逐渐成熟.脾静脉汇合部受累者提倡积极重建,可选用脾静脉原位重建或脾静脉-左肾静脉分流术.低位静脉侵犯的处理最具挑战性,可通过血管整形技术行多支静脉束支重建;超低位广泛侵犯者可选择离体切除联合自体小肠移植.静脉重建应避免使用移植物,长节段切除者推荐采用Cattell-Braasch游离实现免移植物对端吻合.动脉切除重建虽对术者技术要求高、围手术期风险大,但可为转化治疗生物学反应良好者带来显著生存获益.动脉鞘剥除及动脉切除重建已在高容量中心成熟开展.针对合并门静脉闭塞及海绵样变的复杂病例,静脉转流优先策略可有效提升手术安全性与可控性.科学化的外科决策、精准的术前规划、精致的血管重建技术,是提升胰腺癌手术安全性与根治性的关键.未来需推动手术流程规范化与培训体系建设,以使更多血管受累的胰腺癌病人获益.
Pancreatic cancer is often ineligible for upfront surgery at diagnosis due to vascular involvement.Under the precision surgery paradigm,resectability assessment should shift from anatomical to biological criteria,and from"resectability"to"reconstructability",with dynamic evaluation of tumor biology guiding optimal surgical timing.Preoperative precision vascular assessment is essential for individualized surgical planning.Venous reconstruction techniques are well established.Splenic vein reconstruction is recommended for involvement of the spleno-portal confluence.Low-level venous involvement remains challenging,multi-branch reconstruction of the jejunal venous trunks can be achieved via vascular plastic techniques,while extensive low-level involvement may necessitate ex vivo resection with intestinal autotransplantation.Graft interposition should be avoided whenever possible;the Cattell-Braasch maneuver enables graft-free end-to-end anastomosis for long-segment venous resection.Arterial resection and reconstruction,though technically demanding and associated with significant perioperative risks,confers a survival benefit in patients with a favorable response to conversion therapy.Arterial divestment and resection have been proven safe and feasible in high-volume centers.The venous bypass-first strategy improves safety in complex cases with portal vein occlusion and cavernous transformation.Precise preoperative planning and vascular reconstruction techniques,and standardized surgical strategies are key to improving the safety and radicality of pancreatic cancer surgery.Future efforts should focus on promoting standardized surgical protocols and training systems to benefit more patients with vascular involvement.
唐炳钧;王学栋;董家鸿
清华大学附属北京清华长庚医院肝胆胰中心,北京 102218清华大学附属北京清华长庚医院肝胆胰中心,北京 102218清华大学附属北京清华长庚医院肝胆胰中心,北京 102218
医药卫生
胰腺癌血管侵犯血管切除重建局部进展期胰腺癌精准外科
pancreatic cancervascular invasionvascular resection and reconstructionlocally advanced pancreatic cancerprecision surgery
《中国实用外科杂志》 2026 (8)
1029-1036,8
National Natural Science Foundation of China(No.02359301) 国家自然科学基金项目(No.02359301)
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