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人体代谢舱在脂代谢异常相关疾病诊治中的价值OA

Value of human metabolic chambers in the diagnosis and treatment of lipid metabolism disorder-related diseases

中文摘要英文摘要

脂代谢异常相关疾病的核心是能量代谢失衡,表现为底物利用紊乱和代谢灵活性下降.人体代谢舱作为能量代谢测定的"金标准"之一,通过间接测热法实现能量消耗的精准测定,正从科研工具向临床精准诊治平台转化.文章聚焦代谢舱在揭示脂代谢异常机制、重构疾病诊断维度、指导个体化干预中的深层价值,并提出在临床实践中普及间接测热法、构建中国人群代谢测量标准的必要性.随着智慧代谢舱平台的发展,代谢舱有望引领脂代谢异常相关疾病进入真正的精准医疗时代.

The core of lipid metabolism disorder-related diseases lies in imbalance of energy metabolism,which is characterized by disordered substrate utilization and reduced metabolic flexibility.As one of the"gold standards"for measuring energy metabolism,the human metabolic chamber enables precise assessment of energy expenditure through indirect calorimetry and is being transformed from a research tool into a platform for clinical precision diagnosis and treatment.This review focuses on the profound value of metabolic chambers in elucidating the mechanisms underlying lipid metabolism abnormalities,reconstructing diagnostic dimensions of disease,and guiding individualized interventions.It also highlights the necessity of promoting the clinical application of indirect calorimetry and establishing metabolic measurement standards for the Chinese population.With the development of intelligent metabolic chamber platfor.

成艺坪;邵珊珊;赵家军

内分泌糖脂代谢与脑老化教育部重点实验室 山东第一医科大学附属省立医院内分泌代谢病科 山东省糖尿病与代谢疾病临床医学研究中心,山东济南 250021内分泌糖脂代谢与脑老化教育部重点实验室 山东第一医科大学附属省立医院内分泌代谢病科 山东省糖尿病与代谢疾病临床医学研究中心,山东济南 250021内分泌糖脂代谢与脑老化教育部重点实验室 山东第一医科大学附属省立医院内分泌代谢病科 山东省糖尿病与代谢疾病临床医学研究中心,山东济南 250021

医药卫生

脂代谢异常相关疾病人体代谢舱能量代谢精准医学

lipid metabolism disorder-related diseaseshuman metabolic chamberenergy metabolismprecision medicine

《中国实用内科杂志》 2026 (8)

654-658,5

国家自然科学基金(82130025)

10.19538/j.nk2026080106

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