脂代谢异常对肿瘤的影响与脂代谢靶向治疗OA
Impact of abnormal lipid metabolism on tumors and targeted lipid metabolism therapy
脂代谢异常是肿瘤恶性进展、免疫逃逸及治疗抵抗的关键驱动因素.文章系统阐述了脂代谢重编程在促癌、抑制免疫反应及治疗耐药中的多维机制,并总结靶向脂代谢关键节点的治疗策略.深入理解脂代谢调控网络,有望为克服治疗耐药、实现肿瘤精准治疗提供新思路.
Lipid metabolic dysfunction is a critical driver of malignant progression of tumor,immune evasion,and therapeutic resistance.This review systematically delineates the multifaceted mechanisms of lipid metabolic reprogramming in promoting cancer,suppressing immunity,and managing drug resistance,and summarizes therapeutic strategies targeting key points of lipid metabolism.A deeper understanding of lipid metabolic regulatory networks may offer new ideas for overcoming treatment resistance and achieving precision treatment of tumors.
左祥瑞;刘芳芳;褚倩
华中科技大学同济医学院附属同济医院肿瘤科,湖北武汉 430030华中科技大学同济医学院附属同济医院肿瘤科,湖北武汉 430030华中科技大学同济医学院附属同济医院肿瘤科,湖北武汉 430030
医药卫生
脂代谢重编程肿瘤免疫逃逸治疗抵抗
lipid metabolic reprogrammingtumorimmune evasiontherapeutic resistance
《中国实用内科杂志》 2026 (8)
632-640,9
国家科技重大专项子课题(2024ZD0519700,2024ZD0519702)湖北省自然科学基金创新研究群体项目(2026AFA036)国家自然科学基金面上项目(82472969)
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