胰腺炎的代谢视角——脂代谢异常在胰腺炎及内外分泌并发症中的病理枢纽OA

Hypertriglyceridemia has emerged as the second leading cause of acute pancreatitis.Circulating overloads of triglycerides and their hydrolytic products,free fatty acids,trigger pancreatic exocrine and endocrine cellular dysfunction and inflammatory infiltration through mechanical obstruction,chemical toxicity,and ectopic lipid deposition,serving as the core pathological hub driving disease aggravation and recurrence.This review systematically elucidates the pathological cascade mediated by dysregulated lipid metabolism,which encompasses inflammation driving,acinar injury,fibrotic remodeling,and malignant transformation,and evaluates the clinical value of lipid metabolism-related biomarkers along with their potential for long-term intervention.It is emphasized that dysregulated lipid metabolism persists throughout the entire disease course.Thus,the clinical paradigm must urgently shift from localized symptomatic management of pancreatitis toward a lipid homeostasis-centered,full-cycle management of pancreatitis syndrome.Correcting lipid disorders through multidisciplinary collaboration is essential to mitigating acute inflammation,preserving exocrine and endocrine functions,and improving long-term outcomes of patients.