阿司匹林、低分子量肝素在产科应用的循证思考OA
Evidence-based considerations on the application of aspirin and low-molecular-weight heparin in obstetrics
作为抗血小板集聚的主要药物——阿司匹林,以及作为抗凝剂药物的主要药物——低分子量肝素(LMWH),已经广泛应用于妊娠期与产褥期妇女.通过人群筛查,阿司匹林、LMWH分别用于子痫前期高危人群、血栓栓塞高风险人群的预防.此外,阿司匹林联合LMWH应用于抗磷脂综合征、系统性红斑狼疮等自身免疫系统疾病患者,可降低此类患者不良妊娠结局.妊娠期使用阿司匹林、LMWH是否增加产科出血,仍然值得关注.
Aspirin,the main drug used to prevent platelet aggregation,and low-molecular-weight heparin(LM-WH),the main anticoagulant,have been widely used in pregnant and postpartum women.Through population screening,aspirin is used to prevent preeclampsia in high-risk groups,while LMWH is used to prevent thromboembo-lism in high-risk groups.In addition,combining aspirin with LMWH in patients with autoimmune diseases like an-tiphospholipid syndrome or systemic lupus erythematosus can reduce adverse pregnancy outcomes.Whether using as-pirin and LMWH during pregnancy increases the risk of ob-stetric bleeding is still worth paying attention to.
曾桢;杨祥群;陈敦金
清华大学附属北京清华长庚医院妇产中心,北京 102218广州医科大学附属第三医院妇产科,广东 广州 510150广州医科大学附属第三医院妇产科,广东 广州 510150||广东省产科重大疾病重点实验室,广东 广州 510150
医药卫生
阿司匹林低分子量肝素子痫前期静脉血栓栓塞症抗磷脂综合征
aspirinlow-molecular-weight heparinpre-eclampsiavenous thromboembolismantiphospholipid syndrome
《中国实用妇科与产科杂志》 2026 (8)
806-810,5
国家重点研发计划"生育健康及妇女儿童健康保障"重点专项项目(2022YFC2704500)贵州省科技计划项目面上项目[黔科合基础MS(2025)698]2025年度广州市科技局市校(院)企联合资助项目基础研究计划(2025A03J3765) Key Program of National Key Research and Development Program of China'Reproductive Health and Women and Children's Health Protection'(2022YFC2704500)Guizhou Provincial Science and Technology Plan-General Program[Qian Ke He Basic MS(2025)698]2025 Guangzhou Municipal Science and Technology Bureau University(Institute)Enterprise Joint Funding Project-Basic Research Plan(2025A03J3765)
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