首页|期刊导航|中国实用妇科与产科杂志|自然流产的辅助检查和过度检查

自然流产的辅助检查和过度检查OA

Auxiliary testing and overtesting for spontaneous abortion

中文摘要英文摘要

自然流产的辅助检查主要包括对该次妊娠状态及母体安全的评估,以及根据流产次数、孕周和临床特征开展的病因学评估,为后续妊娠管理提供依据.早期自然流产应以经阴道超声为主要检查手段,必要时结合血清β-人绒毛膜促性腺激素(β-hCG)动态变化及临床表现,判断妊娠部位、胚胎存活情况和妊娠囊数目;晚期自然流产除评估胎儿存活情况外,还应重点关注子宫颈、胎膜、胎盘、胎儿生长发育及母体并发症.单次且无特殊高危因素的自然流产通常无需开展全面病因筛查;复发性流产(recurrent spontaneous abortion,RSA)患者则应结合既往妊娠史和临床表型,围绕遗传因素、子宫及宫腔结构、抗磷脂综合征及凝血相关因素、内分泌代谢异常、自身免疫性疾病、感染相关和男性相关因素进行分层评估.当前自然流产诊疗中仍存在过度检查的现象,可能导致异常结果过度解读、无循证依据的治疗,并增加患者的心理及经济负担.自然流产辅助检查应以循证医学证据为依据,综合考虑检测方法的可靠性、适用人群、检查结果对临床决策的影响,以及相应干预能否改善妊娠结局,由无差别的全面筛查转向有针对性的分层评估,减少不必要的检查和干预.

Auxiliary testing for spontaneous abortion pri-marily includes assessment of the status of the current preg-nancy and maternal safety,as well as etiological evaluation based on the number and gestational age of previous preg-nancy losses and the patient's clinical characteristics,thereby providing a basis for the management of subse-quent pregnancies.In early spontaneous abortion,transvag-inal ultrasonography should be the principal diagnostic mo-dality.When necessary,dynamic changes in serum β-hu-man chorionic gonadotropin and clinical findings should be incorporated to determine the location of the pregnancy,embryonic viability,and the number of gestational sacs.In late spontaneous abortion,in addition to assessing fetal via-bility,particular attention should be paid to the cervix,fetal membranes,placenta,fetal growth and development,and maternal complications.A single spontaneous abortion in the absence of specific high-risk factors generally does not warrant comprehensive etiological investigation.By con-trast,patients with recurrent spontaneous abortion should undergo stratified evaluation based on their reproductive history and clinical phenotype,with attention paid to genet-ic factors,uterine and intrauterine structure,antiphospho-lipid syndrome and coagulation-related factors,endocrine and metabolic disorders,autoimmune diseases,infection-related factors,and male-related factors.Excessive testing remains common in the clinical management of spontane-ous abortion at present,and may lead to overinterpretation of abnormal findings,treatment without an adequate evi-dence base,and increased psychological and financial bur-dens on patients.Auxiliary testing for spontaneous abortion should therefore be guided by evidence-based medicine,with consideration given to the reliability of the testing method,the target population,the influence of the findings on clinical decision-making,and whether the correspond-ing intervention can improve pregnancy outcomes.Clinical practice should shift from indiscriminate comprehensive screening to targeted,stratified evaluation,thereby reduc-ing unnecessary testing and interventions.

陈慧

中山大学孙逸仙纪念医院妇产科,广东 广州 510120

医药卫生

自然流产复发性流产辅助检查过度检查循证医学

spontaneous abortionrecurrent spontaneous abortionauxillary testingovertestingevidence-based medicine

《中国实用妇科与产科杂志》 2026 (8)

775-781,7

重大疑难疾病中西医临床协作项目(ZDYN-2024-A-073)广东省自然科学基金(2024A1515013264) Major Difficult and Complicated Diseases Integrated Traditional Chinese and Western Medicine Clinical Collaboration Project(ZDYN-2024-A-073)Guangdong Provincial Natural Science Foundation(2024A1515013264)

10.19538/j.fk2026080102

评论