龙胆泻肝汤加减对热毒蕴结证肛周脓肿术后患者创面愈合及炎症因子的影响OA

Objective:To observe the effects of modified Longdan Xiegan Tang on wound healing and inflammatory factors after surgery for perianal abscess of heat-toxin accumulation syndrome.Methods:A prospective randomized controlled design was adopted.A total of 110 patients with perianal abscess of heat-toxin accumulation syndrome admitted to Hebei Provincial Hospital of Traditional Chinese Medicine from January 2024 to January 2025 were included and randomly assigned into two groups,each with 55 patients according to the random number table method.The control group received conventional Western medicine treatment+placebo oral administration after surgery,and the observation group received modified Longdan Xiegan Tang oral administration on the basis of conventional Western medicine treatment,with a course of 14 days.Clinical efficacy,Visual Analogue Scale(VAS)score,wound secretion score,TCM symptom score,wound healing rate,wound healing time,wound infection rate,inflammatory factors[interleukin-6(IL-6),interleukin-8(IL-8),and tumor necrosis factor-α(TNF-α)],wound healing-related indicators[fibronectin(FN),matrix metalloproteinase-9(MMP-9),and prealbumin(PA)]and adverse reactions were determined in both groups.Results:Three cases in the observation group and three cases in the control group dropped out,with 104 cases actually completing the study.The repeated measures analysis of variance showed that both groups showed decreased VAS scores,wound secretion scores,TCM syndrome scores,and levels of IL-6,IL-8,TNF-α,and MMP-9 and increased levels of PA and FN after treatment(P<0.05).During treatment and on day 14 after surgery,the observation group had lower VAS score,wound secretion score,TCM syndrome score,and levels of IL-6,IL-8,TNF-α,and MMP-9 and higher levels of PA and FN than the control group(P<0.01).The observation group showed higher wound healing rate,shorter wound healing time,and lower wound infection than the control group(P<0.01).The comprehensive efficacy of the observation group was better than that of the control group(χ2=5.216,P<0.05).No serious adverse events occurred in patients during the study,and there was no significant difference in the incidence of adverse reactions between the two groups.Conclusion:Modified Longdan Xiegan Tang can ameliorate wound condition,reduce inflammatory response,and promote wound healing in patients with perianal abscess of heat-toxin accumulation syndrome after surgery,with good safety.