子宫内膜异位症病证结合动物模型的建立及评价方法研究OA
Establishment and evaluation methods of animal models of endometriosis
子宫内膜异位症(EMs)是一种常见妇科疾病,可引起骨盆疼痛和不孕症,且近年来子宫内膜异位症的发病率呈上升趋势.中医药在治疗EMs方面具有丰富的临床经验,具有副作用小并减少复发等优势,建立疾病和中医证候双重特征的EMs病证结合动物模型对于深入研究EMs具有重要意义.文章综述了EMs常见证型气滞血瘀型、寒凝血瘀型、肾虚血瘀型、气虚血瘀型、热灼血瘀型证候动物模型的制备方法及评价指标,为后续中医临床的辨证论治提供一定的理论背景.
Endometriosis(EMS)represents a prevalent gynecological disorder capable of inducing pelvic pain and infertility.There has been an upward trend in the incidence of endometriosis in recent years.Traditional Chinese medicine(TCM)has demonstrated extensive clinical experience in treating endometriosis,with advantages such as minimal side effects and a reduced recurrence rate.It is important to establish an animal model of endometriosis with the dual characteristics of disease and TCM syndromes to support its further study.This review presents the preparation method and evaluation indexes of animal models of the common syndromes of endometriosis,such as qi stagnation and blood stasis type,cold coagulation and blood stasis type,kidney deficiency and blood stasis type,qi deficiency and blood stasis type,and heat burning and blood stasis type.The aim is to provide a theoretical foundation for subsequent syndrome-differentiation and treatment in TCM clinical practice.
施恭宁;徐陈琳;付欣慧;冯晓雨;焦坤;童黄锦
南京中医药大学附属中西医结合医院,南京 210028||中药制药过程控制与智能制造技术全国重点实验室,南京中医药大学,南京 210023南京中医药大学附属中西医结合医院,南京 210028||中药制药过程控制与智能制造技术全国重点实验室,南京中医药大学,南京 210023南京中医药大学附属中西医结合医院,南京 210028||中药制药过程控制与智能制造技术全国重点实验室,南京中医药大学,南京 210023南京中医药大学附属中西医结合医院,南京 210028||中药制药过程控制与智能制造技术全国重点实验室,南京中医药大学,南京 210023阜阳市食品药品检验检测中心,安徽阜阳 236000南京中医药大学附属中西医结合医院,南京 210028||中药制药过程控制与智能制造技术全国重点实验室,南京中医药大学,南京 210023
生物科学
子宫内膜异位症病证结合动物模型中医证候模型评价
endometriosiscombination of disease and syndromeanimal modelChinese medicine syndromesmodel evaluation
《中国实验动物学报》 2026 (8)
1196-1210,15
国家自然科学基金项目(82305010),江苏省中药骨干人才高级研修项目(苏中医科教(2022)17号),中药制药过程控制与智能制造技术重点实验室开放基金课题(SKL2024Z0109),江苏省高层次人才培养计划("333工程")培养对象(苏人才(2024)2号,(2024)3-2260号),2025年阜阳市重点研究与开发计划项目(FK20253301).Funded by the National Natural Science Foundation of China(82305010),Jiangsu Province Chinese Medicine Backbone Talent Advanced Training Project(Jiangsu Traditional Chinese Medicine Science and Education(2022)No.17),Open Fund Project of Key Laboratory of Pharmaceutical Process Control and Intelligent Manufacturing Technology of Traditional Chinese Medicine(SKL2024Z0109),the Training Object of Jiangsu Provincial High-Level Talents Training Plan("333 Project")(Su Talents(2024)No.2,(2024)No.3-2260),Fuyang Key Research and Development Plan Project in 2025(FK20253301).
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