心肌缺血再灌注损伤动物模型构建的回顾与评价OA

Acute myocardial infarction exhibits a high global occurrence rate and mortality.The primary therapeutic objective for this condition is to rapidly restore coronary artery blood flow,thereby mitigating the progression of myocardial ischemia and infarction.However,during the restoration of blood perfusion to ischemic tissues,a series of significant pathophysiological alterations frequently occur in cardiac cells and the local microvascular network within the reperfused area.These changes collectively contribute to further damage of the myocardial tissue,a phenomenon referred to as myocardial ischemia-reperfusion injury(MIRI).Currently,the precise pathological mechanisms underlying MIRI have not been systematically elucidated.The lack of animal models that can ideally simulate this pathological process represents one of the critical factors limiting the development of effective prevention and treatment strategies.This article aims to systematically review the method ologies for establishing animal models of myocardial ischemia-reperfusion injury,with the goal of providing a theoretical foundation for related basic research and clinical therapeutic practices.