食源性感染患者沙门菌血清型分布及耐药性分析OA
Analysis of Serotype Distribution and Drug Resistance of Salmonella in Patients with Foodborne Infection-based on the Monitoring Data of a Hospital in Taizhou from 2023 to 2025
目的:基于台州某医院2023-2025年的监测数据分析食源性感染患者沙门菌血清型分布及耐药性.方法:回顾性纳入2023年1月—2025年10月在台州恩泽医疗中心(集团)恩泽医院送检的粪便/肛拭子标本1 585份中检出的207份沙门菌.分析207份沙门菌暴露食品分布、血清型及耐药性结果、多重耐药结果.结果:207份病例中,沙门菌暴露食品占比前四位分别为粮食类及其制品、水果类及其制品、肉与肉制品、乳与乳制品.2023-2025年207份病例中,沙门菌检出的血清型占比较高的均为鼠伤寒沙门菌,占比分别为48.53％、57.97％、51.43％.2023年68份病例中,沙门菌主要对氨苄西林、四环素耐药率高,占比分别为63.24％、55.88％;2024年69份病例中,沙门菌主要对链霉素、氨苄西林耐药率高,占比分别为 59.42％、49.28％;2025年 70份病例中,沙门菌主要对氨苄西林、链霉素耐药率高,占比分别为47.14％、45.71％.多重耐药菌株总体占比为55.56％.结论:2023-2025年该院食源性感染沙门菌以鼠伤寒沙门菌为优势血清型,对氨苄西林、四环素、链霉素的耐药率持续处于较高水平,且多重耐药现象普遍,最常见的耐药模式为氨苄西林-四环素-链霉素三联耐药.
[Objective]To analyze the serotype distribution and drug resistance of Salmonella in patients with food-borne infection based on the monitoring data of a hospital in Taizhou from 2023 to 2025.[Method]A total of 207 Salmonella strains were detected from 1 585 stool/anal swab specimens sent to Enze Hospital of Taizhou Enze Medical Center(Group)from January 2023 to October 2025.The distribution,serotype and drug resistance results and multi-drug resistance results of 207 Salmonella exposed food samples were analyzed.[Result]Among the 207 cases,the top four foods exposed to Salmonella were grain and its products,fruit and its products,meat and meat products,milk and dairy products.The most prevalent Salmonella serotypes in these cases were all Salmonella Typhimurium,accounting for 48.53％,57.97％,and 51.43％in 2023,2024,and 2025,respectively.Among 68 cases in 2023,the resistance rate of Salmonella to ampicillin and tetracycline was high,accounting for 63.24％and 55.88％respectively.Among 69 cases in 2024,the resistance rate of Salmonella to streptomycin and ampicillin was high,accounting for 59.42％and 49.28％respectively.Among 70 cases in 2025,the resistance rate of Salmonella to ampicillin and streptomycin was high,accounting for 47.14％and 45.71％respectively.The overall proportion of multidrug-resistant strains was 55.56％.[Conclusion]From 2023 to 2025,Salmonella typhimurium was the dominant serotype of Salmonella in food-borne infection in the hospital.The resistance rate to ampicillin,tetracycline and streptomycin remained at a higher level,and multi-drug resistance was common.The most common resistance pattern was ampicillin-tetracycline-streptomycin triple resistance.
李洋莹;洪亮;王敏雅;潘艳;叶崇熙
台州市路桥区疾病预防控制中心,浙江 台州 318050台州市食品药品检验研究院/台州市模式动物和临床前药学研究重点实验室,浙江 台州 318050台州市路桥区疾病预防控制中心,浙江 台州 318050台州市路桥区疾病预防控制中心,浙江 台州 318050台州市路桥区疾病预防控制中心,浙江 台州 318050
食源性沙门菌血清型耐药性
food borne salmonellaserotypedrug resistance
《中国食物与营养》 2026 (9)
90-97,8
浙江省药品监管系统科技计划项目(项目编号:2022002).
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