机会性筛查人群胃癌前状态检出现状及影响因素研究OA

Background Gastric precancerous conditions(GPC),including gastric mucosal atrophy and intestinal metaplasia,represent a critical and intervenable stage in the development of gastric cancer.Opportunistic screening serves as an important supplementary model for secondary prevention of gastric cancer in China.However,studies on the detection rate and influencing factors of GPC in opportunistic screening populations are relatively limited.Objective To analyze the detection status of GPC in an opportunistic screening population and to explore related influencing factors,thereby providing evidence-based support for clinicians to accurately identify high-risk individuals and to develop personalized health management strategies.Methods Using convenience sampling,patients undergoing opportunistic screening at Peking Union Medical College Hospital from March to July 2024 were enrolled.Data were collected using a general information questionnaire and the Chinese population gastric cancer risk scoring system(GC-RSS).GPC was determined based on pathological findings from gastroscopic biopsies.Multivariate Logistic regression analysis was performed to identify independent influencing factors for GPC.Results A total of 304 questionnaires were distributed,and 301 valid questionnaires were retrieved,with an effective response rate of 99.0%.Among the 301 patients,the detection rate of GPC was 24.6%(74/301).Multivariate Logistic regression analysis showed that the GC-RSS≥5(OR=2.124,95%CI=1.220-3.698,P<0.05)and previous history of gastric diseases(OR=2.036,95%CI=1.135-3.650,P<0.05)were independent influencing factors for the presence of GPC.Conclusion The detection rate of GPC in the opportunistic screening population is relatively high.Previous history of gastric diseases and GC-RSS≥5 can be used as key indicators for risk stratification.This study provides a preliminary validation of the good predictive value of the GC-RSS in this population.As a non-invasive risk assessment tool,GC-RSS can be used for rapid preliminary screening in general practice clinics or health management processes,thereby advancing the prevention and control of gastric cancer forward to the precancerous stage.